Friability

Friability

Introduction to Tablet Friability Testing

There are a variety of presentations for tablets as a delivery system for pharmaceutical agents. We find: rapidly disintegrating, slowly disintegrating or eroding, chewable and lozenges. Each of these presentations places a certain demand on the bonding, structure and integrity of the compressed matrix. Tablets must be able to withstand the rigors of handling and transportation experienced in the manufacturing plant, in the product distribution system and in the hands of the end user.

One method of measuring the ability of the product to withstand the mechanical stress and to determine their resistance to chipping and surface abrasion is to tumble them in a rotating drum. The percentage of weight loss after tumbling is referred to as the friability of tablets.

Burns Automation supplies equipment which complies with the guidelines of USP Chapter <1216> Tablet Friability.

AE2

Abrasion & Friablity Testers The abrasion and friability testing device consists of two test stations. If required, test drums can be equipped to test for wear due to rolling and falling or to test the abrasion of tablets, tabletcores,...

FRV

Friability Testers (Uncoated Tablets) The basic Friability Tester Model FR 1000/2000 comprises of a single or dual drums rotated at a fixed speed of 25 rpm. The standard friability drum has an inside diameter of 287 mm and a depth of 38 mm...

SA-4000

Friability Testers (Granules and Spheroids) In many cases, such as with hard coated and uncoated tablets, granules and spheroids, it is impossible to determine the friability of the dosage form using a conventional tablet friability tester...