Introduction to Tablet Friability Testing
There are a variety of presentations for tablets as a delivery system for pharmaceutical agents. We find: rapidly disintegrating, slowly disintegrating or eroding, chewable and lozenges. Each of these presentations places a certain demand on the bonding, structure and integrity of the compressed matrix. Tablets must be able to withstand the rigors of handling and transportation experienced in the manufacturing plant, in the product distribution system and in the hands of the end user.
One method of measuring the ability of the product to withstand the mechanical stress and to determine their resistance to chipping and surface abrasion is to tumble them in a rotating drum. The percentage of weight loss after tumbling is referred to as the friability of tablets.
Burns Automation supplies equipment which complies with the guidelines of USP Chapter <1216> Tablet Friability.